Examples Of Sensitization
what is sensitization
Sensitization is a non-relevant learning process, in which repeated stimuli will lead to progressive amplification of responses. Sensitization is usually characterized by an increased response to the entire stimulus category in addition to repeated stimuli. For example, repeated painful stimuli may make a person more sensitive to loud sounds.
When rubbing your arm continuously, you will feel warm due to repeated stimulation of the nerves around the arm. However, after a period of time, this warm feeling will become a painful feeling, so your brain will warn you that rubbing your arm vigorously for a long time will cause you harm and pain. This is a sensitive example.
The concept of sensitization believes that there are specific cell receptors that are expected to respond to stimuli. Once stimulated, the cell receptors will transmit information to and from the brain through peripheral nerves, causing allergies.
In 2000, Eric Kandel won the Nobel Prize in Physiology because he was the first researcher to study the neuronal learning process involving sensitization from the 1960s to the 1970s.
A. Types of sensitization
- Long-term enhancement of LTP:
This sensitization involves electrical or chemical stimulation of the hippocampus (the memory center of the brain) of the organism. Many researchers hypothesize that there are so-called LTP receptors that are responsible for remembering and learning new things.
Just like in LTP, this sensitization also includes the hippocampus of the organism. However, one difference in igniting LTP is the repeated stimulation of hippocampal or amygdala neurons. Ignite seems to be very dangerous because animals studied in the laboratory can cause seizures even if they receive a small amount of stimulation. The discovery of kindling has been used to explain the theory of human temporal lobe epilepsy. In temporal lobe epilepsy, repetitive stimuli (such as flashing lights or turning on and off sounds) can cause seizures. This repetitive stimulus is the reason why people who experience seizures experience this process.
- Central sensitization
This type of sensitization includes pain receptors (called nociceptive neurons) located in the spinal cord. When the surrounding tissues are damaged or inflamed, these pain receptors become sensitive, making people sensitive to the pain they experience. The concept of central sensitization has made a reasonable explanation for the health condition where long-term pain (chronic pain) is a symptom. Therefore, many researchers have developed “desensitization” therapy to reduce long-term pain.
- Drug sensitization
As the name implies, drug allergy occurs when people rely on drugs due to repeated doses.
B. Clinical significance
Sensitization is a useful model when studying pathological root causes such as asthma, substance dependence, allergies, pain-related diseases, and mental illnesses. Now, there are many types of sensitization therapies not only used for medical purposes (allergies, cancer, and other tumors), but also for marriage counseling and family psychotherapy. B. Clinical significance
Sensitization is a useful model when studying pathological root causes such as asthma, substance dependence, allergies, pain-related diseases, and mental illnesses. Now, there are many types of sensitization therapies not only used for medical purposes (allergies, cancer, and other tumors), but also for marriage counseling and family psychotherapy